Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple
نویسندگان
چکیده
منابع مشابه
Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple
1 Department of Medicine, University of California, San Diego, La Jolla, California, USA. 2 Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA. 3 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA. 3 Department of Computer Science and Engineering, Jacob’s School of Engineerin...
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Activation of certain classes of G protein-coupled receptors (GPCRs) can lead to alterations in the actin cytoskeleton, gene transcription, cell transformation, and other processes that are known to be regulated by Rho family small-molecular-weight GTPases. Although these responses can occur indirectly via cross-talk from canonical heterotrimeric G protein cascades, it has recently been demonst...
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15 صفحه اولGuanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs
BACKGROUND During the translation of mRNA into polypeptide, elongation factor G (EF-G) catalyzes the translocation of peptidyl-tRNA from the A site to the P site of the ribosome. According to the 'classical' model, EF-G in the GTP-bound form promotes translocation, while hydrolysis of the bound GTP promotes dissociation of the factor from the post-translocation ribosome. According to a more rec...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2018
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.aao4220